Melani began studying singing in 1994 with Liliana Poli continuing, first with Franco Corellì, then with Susanna Rigacci and Carlo Meliciani.
Finalist at the 40th Verdian Voices Competition "Città di Busseto" (June 2000) and at the V "Maria Callas" New Voices for Verdi Competition (October 2000), he made his debut as Flavio alongside June Anderson's "Norma" and at the Adalgisa of Daniela Barcelona. (Verdi Festival 2001 Teatro Regio di Parma). In May 2001, at the Manzoni Theater in Pistoia, he plays Edgardo in G. Donizetti's “Lucia di Lammermoor”. It made its debut in November '01, in Il Cappello di Paglia di Firenze by Nino Rota as the protagonist (Fadínard), at the Teatro del Giglio in Lucca, an opera brought in toumé in the theaters of Pisa, Livorno, Mantua and Ravenna, enjoying wide acclaim from the public and criticism. In November '02, at the Teatro La Gran Guardia in Livorno, he sang the role of Fritz Kobus in "L 'Amico Fritz" by P. Mascagni. It is Alfredo in "La Traviata" for the Estate Fiesolana and for Taormina Arte in the summer of 2003, Rodolfo in "La Bohème" by G. Puccini, an engagement which was followed, in September 2003, by a solo tour in Japan in the cities of Tokyo, Kanazawa and Nakajima. He sang at the Sao Carlos Theater in Lisbon, at the Zurich Opera House, at the Zarzuela Theater in Madrid, at the Massimo in Palermo, at the Verdi Theater in Busseto and at the Teatro del Maggio Musicale Fiorentino.